CompletedNot Applicable

Hemodynamic Effects of Variations in Net Ultrafiltration Rate During Continuous Renal Replacement Therapy.

France39 participantsStarted 2023-10-06

Plain-language summary

Net ultra filtration (NUF) is one of the most important parameters during renal replacement therapy (RRT) whose role is to control fluid balance by water removal. To our knowledge, there are no prospective studies or guidelines about the setting of this parameter. In the NEPTUNE study, we aim to compare the hemodynamic effect of three NUF rates during RRT: 1 ml/kg/h, 2 ml/kg/h and 3 ml/kg/h. The research hypothesis is that one of the three flow rates evaluated induces the fewest hemodynamic instabilities related to RRT, while guaranteeing the best possible fluid balance.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. weight gain ≥ 1 kg relative to entry weight
✓. oligo-anuria ≥ 24 hours
✓. clinical impact of fluid overload as judged by the clinician: acute lung oedema clinical or at CT-scan, difficulty of weaning from mechanical ventilation.
✓. absence of vasopressors (noradrenaline) or stability or reduction in their dosage
✓. no need for resuscitative fluids as judged by the clinician

What they're measuring

Occurrence of HIRRT

Timeframe: 6 hours

Trial details

NCT IDNCT06071026

SponsorCentre Hospitalier Universitaire de Nīmes

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-07-08

View on ClinicalTrials.gov More Fluid Overload trials