Effects of Fluid Resuscitation on Capillary Refilling Time and Organ Functions in Septic Shock (NCT06067516) | Clinical Trial Compass
CompletedNot Applicable
Effects of Fluid Resuscitation on Capillary Refilling Time and Organ Functions in Septic Shock
Turkey (Türkiye)44 participantsStarted 2023-10-25
Plain-language summary
Since the ultimate target of resuscitation is the microcirculation, normal microcirculatory perfusion appears to be the primary target of ideal resuscitation in septic shock patients. In septic shock patients, microcirculation of the skin may be impaired in the early period due to early sympathetic nervous system activation.
Assessment of skin perfusion has also become popular in shock resuscitation because it is easily accessible for clinical assessment. Studies in septic shock patients, showed that capillary refill time correlated with lactate levels measured at 6 hours of resuscitation and was associated with mortality. Additionally, early normalization of capillary refill time has been associated with improved survival in septic shock This study aimed to evaluate the relationship between the change in capillary filling time (microcirculation) and organ perfusion after fluid resuscitation in sepsis patients in intensive care.
Who can participate
Age range
18 Years – 90 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Over 18 years old
* Admitted to intensive care with a diagnosis of sepsis or septic shock
* Systolic blood pressure \< 90 mmHg or Mean blood pressure \< 65 mmHg
* Those who need vasopressor medication
* Urine output \< 0.5 ml/kg/h for at least two hours
* Tachycardia (Heart rate \> 100/min)
* Serum Lactate \> 2 mmol/L
* Patients with central venous oxygen saturation (ScvO) \< 70%
Exclusion Criteria
* Not approved by the patient or his/her guardian
* Known heart, kidney, liver failure
* The initial cause of shock is neurogenic, cardiogenic or obstructive shock.
* Pregnancy or suspected pregnancy
* Those with amputation or severe organ ischemia
* Those with peripheral artery disease
* Cannot be evaluated optimally with transthoracic echo
* Patients who died in the first 24 hours
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.