CompletedNot Applicable

Host Immune and Metabolic Determinants of Sexual Conversion in Plasmodium Parasites IMMETASEX

Belgium, Burkina Faso, Mozambique458 participantsStarted 2023-12-13

Plain-language summary

Understanding the sexual conversion of the malaria parasite is essential to interrupt malaria transmission. A new tool is developed that, based on expression analysis of sexual stage biomarkers, will estimate sexual conversion rates in natural infections.

Who can participate

Age range1 Year

SexALL

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Inclusion criteria

✓symptomatic for P. falciparum
✓/Travel to P. falciparum endemic area within the last month
✓. Impaired consciousness: A Blantyre coma score \< 3 (when patients are ≤ 6 years) or Glasgow coma score \< 10 (when patients are ≥ 6 years).
✓. Prostration: Generalized weakness so that the person is unable to sit, stand or walk without assistance.
✓. Multiple convulsions: More than two episodes within 24 hours.
✓. Clinical manifestation of respiratory distress (e.g., rapid, deep and labored breathing).

What they're measuring

To validate a Sexual Conversion Estimator tool

Timeframe: 2023-2025

Trial details

NCT IDNCT06064591

SponsorInstitute of Tropical Medicine, Belgium

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-12-09

View on ClinicalTrials.gov More Severe Malaria trials