By InvitationNot Applicable

Project OASIS: Optimizing Approaches to Select Implementation Strategies

United States8,020 participantsStarted 2024-02-01

Plain-language summary

Barriers that prevent healthcare methods supported by science from being adopted in the real world have led to low-quality, inequitable medical care. Implementation science aims to bridge the evidence-to-practice gap but still lacks simple and convenient methods to identify implementation barriers, systematically track which strategies work to improve care, and provide accessible data and expert recommendations to guide implementation strategy selection for use in research and practice. Project OASIS (Optimizing Approaches to Select Implementation Strategies) will conduct a hybrid type-III, cluster-randomized trial of a new decision aid tool that matches site variables and barriers to successful implementation strategies.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Veterans: * Veterans with two outpatient or one inpatient codes for cirrhosis or its complications who had an encounter in the prior 18 months at a participating VA medical center VA clinicians: * Physicians, advance practice providers, nurses, leadership, and staff engaged with selecting and applying implementation strategies to improve care at a participating VA medical center Exclusion Criteria: * Veterans post-transplant or with active hepatocellular carcinoma

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Reach as assessed by hepatocellular carcinoma (HCC) screening rates

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Effectiveness as assessed by patient outcomes

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Adoption as assessed by % improvement in HCC screening performance

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Implementation as assessed by fidelity to HCC screening recommendations

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Maintenance as assessed by maintenance of other measures

Timeframe: 6 months post-intervention

Trial details

NCT IDNCT06061328

SponsorVA Office of Research and Development

Sponsor typeFED

Study typeINTERVENTIONAL

Primary completion2027-10-31

View on ClinicalTrials.gov More Cirrhosis trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Reach as assessed by hepatocellular carcinoma (HCC) screening rates

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Effectiveness as assessed by patient outcomes

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Adoption as assessed by % improvement in HCC screening performance

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Implementation as assessed by fidelity to HCC screening recommendations

Timeframe: measured quarterly 1 year pre-intervention through 6 months post-intervention

Maintenance as assessed by maintenance of other measures

Timeframe: 6 months post-intervention