The goal of this clinical trial is to explore the role of wheat and corn germ blended oils in regulating oxidative stress and immunomodulation in dyslipidaemic populations, to explore their effects on intestinal flora, antioxidant and immunomodulation. The main questions it aims to answer are: * How does phytosterol-rich wheat corn germ blended oil affect oxidative stress and immune function in dyslipidaemic people compared to peanut oil? * How does phytosterol-rich wheat corn germ blended oil affect serum metabolites, serum fatty acid profile, and intestinal flora in dyslipidaemic populations compared to peanut oil? What are the specific mechanisms involved? Participants will be randomly assigned to the intervention and control groups, the packaging of germ oil and peanut oil will have a uniform appearance, and participants will be instructed to replace their household cooking oils with the distributed cooking oil for three months, in addition to replacing all the canteens in the staff units with the trial oil for more than three months. Participants did not know who was the control oil, germ oil or peanut oil, and both were randomly distributed to different groups of participants by the third-party supervisors. Researchers will compare peanut oil to see if phytosterol-rich germ oil can improve oxidative stress and immune function in dyslipidaemic populations, in addition to exploring possible underlying mechanisms of improvement using multi-omics techniques.
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Height in metres
Timeframe: 12 weeks
Weight in kilogram
Timeframe: 12 weeks
body mass index (BMI)
Timeframe: 12 weeks
waist circumference
Timeframe: 12 weeks
hip measurement
Timeframe: 12 weeks
Systolic blood pressure
Timeframe: 12 weeks
diastolic blood pressure
Timeframe: 12 weeks
Serum triglyceride concentrations
Timeframe: 12 weeks
Serum triglycerides concentrations
Timeframe: 12 weeks
Serum LDL cholesterol concentrations
Timeframe: 12 weeks
Serum HDL cholesterol concentrations
Timeframe: 12 weeks
Percentage of CD3+ total T cells
Timeframe: 12 weeks
Percentage of CD4+ T cells
Timeframe: 12 weeks
Percentage of CD8+ T cells
Timeframe: 12 weeks
Percentage of CD4+ CD8+ cells
Timeframe: 12 weeks
Percentage of CD19+ B cells
Timeframe: 12 weeks
Percentage of CD16/56+ NK cells
Timeframe: 12 weeks
Immunoglobulin G
Timeframe: 12 weeks
Immunoglobulin A
Timeframe: 12 weeks
Immunoglobulin M
Timeframe: 12 weeks
Complement C3
Timeframe: 12 weeks
Immunoglobulin E
Timeframe: 12 weeks
reactive oxygen species
Timeframe: 12 weeks
superoxide dismutase
Timeframe: 12 weeks
malondialdehyde
Timeframe: 12 weeks
glutathione
Timeframe: 12 weeks