Magnetic Resonance Imaging (MRI) and Eye-tracking Predictive Markers of Cognitive Ageing. (NCT06058897) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Magnetic Resonance Imaging (MRI) and Eye-tracking Predictive Markers of Cognitive Ageing.
France100 participantsStarted 2024-03-22
Plain-language summary
This research proposes to investigate physiological and cognitive markers of locus coeruleus (LC) neuronal integrity and function in cognitively-healthy participants over 60 years old. The locus coeruleus is a brainstem nucleus, sole source of noradrenaline for the brain. Tau pathology appears in neurons of this nucleus, which may induce initial cognitive changes. The study aims at relating locus coeruleus markers, assessed with MRI and eye-tracking techniques, with cognitive function.
Who can participate
Age range
60 Years – 100 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* INSPIRE cohort participant
* Mini-Mental State Examination score ≥ 27 on 30
* Access to a web connection from participant's or relative's home and regular use of web surfing
* Signature of the informed consent
* Affiliated to a social security scheme
Exclusion Criteria:
* Any contra-indications to MRI exam
* Ophthalmic pathology impacting eye-tracking measures
* Neurological or psychiatric pathology
* Person under guardianship or curatorship
Contraindications to MRI examination:
* Pacemaker or cardiac defibrillator
* Implanted material activated by an electrical, magnetic or mechanical system
* Haemostatic clips for intracerebral aneurysms or carotid arteries
* Orthopedic implants
* Claustrophobia
Ophthalmological pathologies impacting eye tracking measurements:
* Glaucoma
* Age-related macular degeneration
* Unoperated cataract
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Imaging contrast between the LC nucleus and the pontine tegmentum region