Spatial-Motor Stroke-Rehab Study (NCT06053320) | Clinical Trial Compass
RecruitingNot Applicable
Spatial-Motor Stroke-Rehab Study
United States65 participantsStarted 2023-04-11
Plain-language summary
The purpose of this study is to understand how prism adaptation training with and without electrical stimulation changes visuospatial behavior, motor system neurophysiology, and walking dysfunction.
Who can participate
Age range18 Years – 90 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Young Adults Able Bodied (YAB) Individuals
* 18-30 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
Older Adults Able-Bodied Individuals (OAB)
* 45-90 years
* Able-Bodied (healthy without any physical disability or neurological disorder)
Individuals with right hemisphere stroke (40-90 years)
* \>3 months following stroke.
* Presence of Aiming SN
* Ability to walk \>10m with or without assistive devices.
* Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale
* Ability to follow 3-stage commands and provide informed consent.
Exclusion Criteria:
Young Adults Able Bodied (YAB) Individuals and Older Adults Able-Bodied Individuals (OAB)
* History or evidence of orthopedic or physical disability
* History or evidence of neurological pathology
* Pregnancy (female)
* Uncontrolled hypertension
* Cardiac pacemaker or other implanted electronic system
* Presence of skin conditions preventing electrical stimulation setup
* Impaired sensation in the left upper limb.
* Bruises or cuts at the stimulation electrode placement site
* Concurrent enrollment in rehabilitation or another investigational study.
* History or evidence of orthopedic or physical disability interfering with study procedures
* History or evidence of neurological pathology or disorder
* Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active canc…
What they're measuring
1
Change in visuospatial pointing behavior
Timeframe: Pre-training and immediately after training session
2
Change in intracortical excitability [paired pulse transcranial Magnetic Stimulation (TMS)]
Timeframe: Pre-training and immediately after training session
3
Change in corticospinal excitability (single pulse TMS)
Timeframe: Pre-training and immediately after training session