A Study of DISC-3405 in Healthy Volunteers

Inclusion Criteria: * Healthy male and female subjects, non-smokers, ages 18-65 (inclusive) at the time of signing the informed consent * No clinically significant medical history and in good health as determined by detailed medical history * Body mass index (BMI) 18.0 - 33.0 kg/m2 (inclusive) and body weight ≥ 50.0 kg for males and ≥ 45.0 kg for females Exclusion Criteria: * History of severe infection within 4 weeks prior to administration; signs and symptoms of any active infection regardless of severity within 2 weeks prior to administration. * History of hypersensitivity to similar drugs to DISC-3405 or their excipients. * Use of any prescription drugs, herbal supplements, or nonprescription drugs, including oral anti-histamines (for seasonal allergies), within 1 month or 5 half-lives (whichever is longer) prior to study drug administration, or dietary supplements within 1 week prior to study drug administration, unless, in the opinion of the Investigator and Sponsor, the medication will not interfere with the study. Over-the-counter multivitamins will not be permitted. If needed, paracetamol/acetaminophen (up to 2 grams daily) may be used but must be documented in the Concomitant medications/Significant non-drug therapies page of the source data. Any questions of concomitant medications should be directed to the Sponsor. * Participation in a clinical research study involving the administration of an investigational or marketed drug or device within 30 days prior to t…