Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Inclusion Criteria: * Patient must be ≥ 18yrs of age. * Patient must have the ability to understand, and the willingness to sign, a written informed consent form. * Patient has been on a stable or decreasing dose of steroids for at least five days prior to the date of informed consent. * Any toxicity from prior therapy must be resolved or at maximum Grade 1 prior to initiation of NEO212. * If progression of disease occurs within 90 days or conformal radiation, the progression/recurrence must be outside of the radiation field or proven by biopsy/resection. * Patient with Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype must have a Karnofsky Performance Status (KPS) of ≥ 60. * Patient with select solid tumors must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2. * Patient must have an expected survival or at least three months. * Patient must have a baseline MRI of the brain with gadolinium within 14 days of administration of NEO212. * Patient with select solid tumors must have a baseline CT scan with IV contrast and oral contrast of neck, chest, abdomen and pelvis within 14 days of administration of NEO212. * Patients must be able to comply with all study assessments. * If patient suffers from seizures (s)he must be controlled on a stable dose of anti-epileptics for 14-days prior to the date of informed consent. * Patient must have adequate organ and marrow function as follows: * Absolute neutrophil count ≥ 1,500/microliter * Platelets ≥ 100,…