TerminatedNot Applicable

Virologic and Immunologic Characteristics of Severe Mpox in Persons With Advanced HIV

Stopped: Insufficient participant enrollment

United States100 participantsStarted 2023-03-17

Plain-language summary

The purpose of this study is to examine the extent of mpox viral spread and immunologic markers in people with advanced HIV. Study findings will enhance knowledge of mpox pathogenesis in severely immunocompromised people, which can inform treatment and prevention of severe illness and deaths associated with mpox in people with advanced HIV.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 years; AND * HIV infection with CD4 count \< 200 cells/uL; AND * Probable or confirmed mpox (does NOT need to be a new diagnosis); AND * Hospitalized while symptomatic from mpox, for reasons other than (or in addition to) infection prevention and control Exclusion Criteria: * Inability of the individual or appropriate proxy to provide informed consent. * In the judgment of the clinical treating team, has a medical condition or other factor that might affect their ability to participate in the evaluation.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Monkeypox viral persistence

Timeframe: While hospitalized, for up to 12 months

Monkeypox viral viability

Timeframe: While hospitalized, for up to 12 months

Immune response

Timeframe: While hospitalized, for up to 12 months

Trial details

NCT IDNCT06045923

SponsorCenters for Disease Control and Prevention

Sponsor typeFED

Study typeOBSERVATIONAL

Primary completion2026-01-01

View on ClinicalTrials.gov More Monkeypox trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.