This phase I trial studies the side effects and best dose of autologous CD8+ and CD4+ transgenic T cells expressing high affinity KRASG12V mutation-specific T cell receptors (FH-A11KRASG12V-TCR) and to see how well they work in treating patients with solid tumor cancers that has spread from where it first started (primary site) to other places in the body (metastatic). T cells are infection fighting blood cells that can kill tumor cells. The T cells given in this study will come from the patient and will have a new gene put in them that makes them able to recognize KRAS G12V, a protein on the surface of tumor cells. These KRAS G12V-specific T cells may help the body's immune system identify and kill KRAS G12V solid cancer tumor cells.
Age range
18 Years
Sex
ALL
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Incidence of adverse events
Timeframe: Within 1 year after 1st infusion of (autologous CD8+ and CD4+ transgenic T cells expressing high affinity KRASG12V mutation-specific T cell receptors (FH-A11KRASG12V-TCR)
Dose-limiting toxicity rates
Timeframe: From the time of lymphodepletion chemotherapy to 28 days after FH-A11KRASG12V-TCR infusion
Maximum tolerated dose of FH-A11KRASG12V-TCR
Timeframe: From the time of lymphodepletion chemotherapy to 28 days after FH-A11KRASG12V-TCR infusion
Recommended phase 2 dose of FH-A11KRASG12V-TCR
Timeframe: Within 1 year after 1st infusion of FH-A11KRASG12V-TCR