Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magneti… (NCT06043401) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
United States40 participantsStarted 2023-04-04
Plain-language summary
This study will attempt to use magnetic resonance imaging (MRI) to take a picture of the brain to learn about changes that occur in the brain during Transcranial Magnetic Stimulation (TMS) in people receiving this treatment for depression.
Who can participate
Age range18 Years – 65 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
MDD volunteers:
Inclusion Criteria
* Age 18-65
* Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
* DSM-IV diagnosis of MDD
Exclusion Criteria
* Unable to speak English.
* Contraindicated for MRI.
* Any current or recent untreated medical, neurological, or psychiatric conditions other than MDD that would preclude candidacy for TMS.
* Metal implant devices in the head, heart, or neck.
* History of brain surgery.
* History of cortisol medication use or electroconvulsive therapy.
* History of myocardial infarction or arrhythmia, bradycardia.
* Personal history of recent head injury, concussion, or self-report of moderate to severe traumatic brain injury.
* Individuals suffering from frequent/severe headaches.
* Moderate to severe alcohol or substance use disorder.
* Pregnancy
Healthy Volunteers Inclusion Criteria
* Age 18-65
* Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
Exclusion Criteria
* Unable to speak English.
* Contraindicated for MRI.
* Any current or recent untreated medical, neurological, or psychiatric conditions
* Metal implant devices in the head, heart, or neck.
* History of brain surgery.
* History of cortisol medication use or electroconvulsive therapy.
* Comorbidity with other psychiatric/neurological illnesses or personality disorders
* History of myocardial infarction or arrhythmia, bradycardia.
* Personal history of recent head…
What they're measuring
1
Monitoring brain state renormalization with MRI
Timeframe: Baseline, 3-weeks, and 6-weeks, assessed up to 6 weeks.