Comparison of Quality of Life in Patients with Differentiated Thyroid Carcinoma Undergoing Differ… (NCT06037174) | Clinical Trial Compass
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Comparison of Quality of Life in Patients with Differentiated Thyroid Carcinoma Undergoing Different Surgery
China230 participantsStarted 2023-09-15
Plain-language summary
The incidence of thyroid cancer has increased rapidly in recent years, especially in women. Early differentiated thyroid cancer has a good prognosis, and surgery is the main treatment. Traditional open surgery would leave a scar on the neck. However, emerging minimally invasive procedures can avoid the scar on the neck, resulting in better aesthetic effect, which would have an impact on the quality of life of patients to a certain degree.
This study intend to follow up patients regularly with early differentiated thyroid cancer undergoing different surgery. The quality of life, voice, scar would be assessed by authoritative questionaires or scales. We hope to demonstrate that minimally invasive surgery is better than traditional open surgery in order to provide reliable evidence for clinical practice.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years and \< 70 years;
* Biopsy or surgical pathology indicated differentiated thyroid carcinoma (papillary thyroid carcinoma, follicular carcinoma);
* stage T1\~T3a, N0\~N1a, M0;
* Ability to read and write Chinese;
* Willingness to follow up.
Exclusion Criteria:
* Age \< 18 years old or ≥70 years old;
* Biopsy or surgical pathology indicated medullary carcinoma or anaplastic thyroid carcinoma;
* Aggressive histology: tall cell, columnar cell, hobnail variant, etc.
* Mixed with medullary carcinoma or anaplastic thyroid carcinoma;
* High risk of recurrence (according to ATA guideline);
* Lateral cervical lymph node metastasis or distant metastasis;
* Suffer from other malignant tumors;
* History of thyroid surgery or cervical lymph node dissection;
* Cognition or behavior impairment.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
change of quality of life (SF-36)
Timeframe: baseline, 1month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
2
change of quality of life (Thyca-Qol)
Timeframe: baseline, 1month after surgery, 3 months after surgery, 6 months after surgery, 12 months after surgery
Trial details
NCT IDNCT06037174
SponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen University