CompletedNot Applicable

Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome

Netherlands33 participantsStarted 2019-03-01

Plain-language summary

In this study, investigators seek to determine whether the timing of antibiotics given to mothers during an elective C-section affects the composition of their infant's gut microbiome. To do this, a randomized controlled trial (RCT) was carried out with women undergoing elective C-sections. These women were either given antibiotics before the skin incision (AB+) or after the umbilical cord was clamped (AB-).

Who can participate

Age range1 Year

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Females undergoing elective CS at the UMCG * Gestational age in weeks equal to or above 38 weeks Exclusion Criteria: * Cephalosporin allergy * Exposure to antibiotic agent 2 weeks before CS * Temperature \>37.5 C before CS * Pre-labour rupture of membranes * Emergency CS * No -20 freezer at home * No command of the Dutch language

What they're measuring

Infant microbial species level differences between two groups

Timeframe: First 6 weeks of life

Infant Alpha Diversity differences between two groups

Timeframe: First 6 weeks of life

Infant Beta Diversity differences between two groups

Timeframe: First 6 weeks of life

Infant Antibiotic Resistance total gene load differences between two groups

Timeframe: First 6 weeks of life

Trial details

NCT IDNCT06030713

SponsorUniversity Medical Center Groningen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-10-01

View on ClinicalTrials.gov More Microbial Colonization trials