Measuring Environmental Tobacco and Cannabis: Pollutants and Exposures

Inclusion Criteria: \- Adult nonsmokers, aged 21-50, who: * Are healthy on the basis of medical history * Have systolic blood pressure \<150 * Have diastolic blood pressure \<100 * Have BMI between 18.1 and 34.9 * Able to perform moderate exercise, * Are not exposed to tobacco or cannabis SHS in their daily lives. (Nonsmoking status and low SHS exposure are determined by self-report on the screening questionnaire, salivary cotinine \< 10 ng/ml and THC \< 50 ng/m and exhaled CO2 below 4 ppm) Exclusion Criteria: * Current use of cannabis products, including CBD and edible THC products * Regular exposure to secondhand tobacco or cannabis smoke * Positive SARS-CoV-2 antibody test * Age 18 \< or \> 50 * Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma. * Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications * Systolic blood pressure \> 150 * Diastolic blood pressure \> 100 * Pregnancy or breastfeeding (by urine hCG and/or history) * Alcohol or illicit drug dependence within the past 5 years * BMI \> 35 and \< 18 * Current illicit drug use (by history or urine test) * More than 1 pack year smoking history * Ever a daily marijuana smoker * Smoked anything within the last 2 months * Occupational exposure to smoke, dusts OR fumes * Concurrent participation in another clinical trial * Unable to…