Gluten-free Diet in PSC and IBD

Inclusion Criteria (for PSC group): * Established diagnosis of PSC (based on radiologic features, typical finding on MRCP or ERCP) * Age 18 - 65 years * ALP 1,5x higher than ULN * Signed informed consent Exclusion Criteria (for PSC group): * Patients on gluten-free diet * Patients with coeliac disease or wheat allergy * Liver transplant recipients * PSC/AIH overlap syndrome * Other causes of liver disease * Radiologic or clinical signs of decompensated liver cirrhosis * Advanced liver cirrhosis (MELD score ˃ 15) * Recurrent acute cholangitis or cholangiogenic sepsis in past 3 months * Use of antibiotics in past 3 months * History of malignancy * Pregnant women * Not signed informed consent Inclusion criteria (for UC group): * Ulcerative colitis diagnosed based on clinical, endoscopic and histological findings * Extension of affected colon \> 15cm * Mayo score 0-4 * Signed informed consent Exclusion criteria (for UC group): * CMV, Clostridium difficile enterocolitis in past 3 months * Use of antibiotics in past 3 months * Patients with coeliac disease or wheat allergy * Patients on gluten-free diet * Pregnant women * Not signed informed consent * Biologic therapy * Methotrexate * Prednison \> 10 mg * Not signed informed consent