CompletedNot Applicable

2 Weeks of Citrulline Supplementation on Arterial Function in Postmenopausal Women With Elevated Blood Pressure or Hypertension

United States19 participantsStarted 2023-07-20

Plain-language summary

The objective of this project is to elucidate the effect of L-Citrulline (L-CIT) supplementation on vascular function at rest and during rhythmic handgrip exercise and functional sympatholysis via lower-body negative pressure in postmenopausal women with elevated blood pressure and hypertension.

Who can participate

Age range

50 Years – 70 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Postmenopausal women (defined as the absence of menstruation for at least 1 year). * Resting systolic blood pressure 120-150 mmHg. * Between the ages of 50 - 70 years. * Sedentary (\< 120 minutes of exercise/week). * Body mass index of 25 - 39.9 kg/m2. * Fasting glucose \< 126 mg/dL and HbA1c \< 6.5%. Exclusion Criteria: * Body mass index ≥ 40 or \< 25 kg/m2. * Systolic blood pressure \> 150 mmHg. * Taking more than two antihypertensive medications. * Cardiovascular diseases, type I/II diabetes, musculoskeletal disorders, or cancer. * Changes in hypertensive medication in the past three months. * Began or changed hormone replacement therapy in the past 6 months. * Current smoker. * Heavy drinking (\> 7 alcoholic drinks/week). * Participants on beta-blockers or other vasodilatory supplements (nitrates). * Incorporated in a weight loss program and/or aerobic or resistance training program.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Macrovascular endothelial function at rest

Timeframe: 2 weeks of each intervention

Microvascular endothelial function at rest

Timeframe: 2 weeks of each intervention

Microvascular endothelial function at rest

Timeframe: 2 weeks of each intervention

Brachial artery blood flow at rest and during rhythmic handgrip exercise with and without lower-body negative pressure

Timeframe: 2 weeks of each intervention

Forearm muscle oxygenation at rest and during rhythmic handgrip exercise with and without lower-body negative pressure

Timeframe: 2 weeks of each intervention

Trial details

NCT IDNCT06025383

SponsorTexas Tech University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-01

View on ClinicalTrials.gov More Menopause trials

Who can participate

Age range

50 Years – 70 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Macrovascular endothelial function at rest

Timeframe: 2 weeks of each intervention

Microvascular endothelial function at rest

Timeframe: 2 weeks of each intervention

Microvascular endothelial function at rest

Timeframe: 2 weeks of each intervention

Brachial artery blood flow at rest and during rhythmic handgrip exercise with and without lower-body negative pressure

Timeframe: 2 weeks of each intervention

Forearm muscle oxygenation at rest and during rhythmic handgrip exercise with and without lower-body negative pressure

Timeframe: 2 weeks of each intervention