Effects of L-citrulline Supplementation on Vascular Function in Metabolic Syndrome

Inclusion Criteria: Must present at least 3 of the following 5 cardiometabolic risk factors * Waist circumference ≥88 cm * Fasting glucose between 100-125 mg/dL or HbA1c between 5.7-6.4%. * Blood pressure ≥130 mm Hg * Triglyceride ≥ 150 mg/dL * HDL \<50 mg/dL The following are also inclusion criteria's: * Women aged 45-79 years old * Body mass index ≤ 39.9 kg/m2 * Sedentary (defined as \< 120 min/week of exercise) * Abstain from any dietary supplements with vascular effects for one month prior to the beginning of the study and until participation in study has terminated. Exclusion Criteria: * \< 45 and \> 79 years of age * Use of medications and/or any supplements that may affect outcome variables (such as arginine-containing supplements, nitroglycerin, statin drugs, biguanides, insulin, beta blockers, statins, verapamil) * Systolic blood pressure ≥ 160 mmHg * BMI \> 40 kg/m2 * Recent changes in medication (3 months) * Current smoking any tobacco use * Cardiovascular disease, diabetes (Type 1 or 2), and other metabolic or chronic diseases * More than 7 alcoholic drinks/week of consumption