CompletedNot Applicable

The Importance of Prostaglandin and Nitric Oxide Synthesis in Apical Periodontitis

Turkey (Türkiye)185 participantsStarted 2021-01-07

Plain-language summary

A total of 185 subjects were divided into three categories: AP group (n=85), CP group (n=50) and healthy control group (n=50). The AP group was divided into 3 subgroups according to abscess scoring (AS-PAI) based on the periapical index. The CP group was divided into 4 subgroups according to the periodontitis staging system (PSS). After recording the demographic and clinical characteristics of all participants, blood and gingival crevicular fluid (GCF) samples were taken. TNF-α, IL-10, PGE2 and NO levels were measured in these samples.

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Apical periodontitis (AP) and/or chronic periodontitis (CP) * Patients who had taken antibiotics and/or anti-inflammatory drugs within the last 6 months - - Without periodontal pathology as well as any acute/chronic disease (muscle/joint/bone diseases, inflammatory bowel disease, local or generalized infection, severe organ disease, cardiovascular disease and diabetes mellitus) were included in the study Exclusion Criteria: * with pregnancy or lactation were also excluded. * with a history of using steroid or nonsteroidal anti-inflammatory drugs and high-dose biotin vitamin in the last 48 hours were excluded from the study.

What they're measuring

The inflammatory markers TNF-α, IL-1β, IL-6 and IL-10,17

Timeframe: Through study completion, an average of 1 year

The biomarkers with protective functions such as PGE2 and NO2

Timeframe: Through study completion, an average of 1 year

Trial details

NCT IDNCT06023901

SponsorIstanbul Medipol University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-01-02