RecruitingNot Applicable

Sex Hormones, Postoperative Pain and Opioid Use

United States210 participantsStarted 2023-09-01

Plain-language summary

Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use. Aim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors

Who can participate

Age range11 Years – 16 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Pediatric female patients between the ages 11-16 undergoing an orthopedic (trauma and non-trauma) surgical procedure involving a long bone or joint, or the spine, English speaking Exclusion Criteria: Pregnancy; Diagnosis of chronic pain, Psychiatric, developmental or neurological disorders, Disorders that are associated with pubertal maturation (e.g., precocious puberty).

What they're measuring

Sex hormone level of Testosterone

Timeframe: Baseline

Sex hormone level of estrogen

Timeframe: Baseline

Sex hormone level of progesterone

Timeframe: Baseline

Levels of IL-10 and IL-6

Timeframe: Baseline

Trial details

NCT IDNCT06023225

SponsorWashington University School of Medicine

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-07-01

View on ClinicalTrials.gov More Postoperative Pain trials