Injectable Platelet-Rich Fibrin and Microneedling For Papillae Reconstruction In Esthetic Zone (NCT06021301) | Clinical Trial Compass
UnknownPhase 2
Injectable Platelet-Rich Fibrin and Microneedling For Papillae Reconstruction In Esthetic Zone
Egypt10 participantsStarted 2023-11
Plain-language summary
The currently available non-surgical techniques for papillary reconstruction did not provide long term maintenance of papillary regeneration, Surgical techniques are invasive and the results are unpredictable . The study is based upon the positive effects of iPRF upon enhancing wound healing in terms of new collagen formation, angiogenesis and increasing keratinized tissue phenotype . iPRF exhibited comparable effects to subepithelial connective tissue graft in papillary reconstruction . The effect of microneedling on the tissue responds as if experiencing tissue trauma and the body's own collagen production is induced to preserve tissue integrity . Growth factors are released immediately after injury, inducing the proliferation of new cells, and fibroblasts are transformed into collagen and elastin fibres from day 5 up to week 8 .
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Nonsmoking patients aged above 18 years.
* At least one site with interdental papilla recession in the anterior region of the maxillary or mandibular jaws.
* The distance from the contact point to alveolar bone is crest \< 7 mm.
* Class I or Class II papillary recession, according to Nordland and Tarnow's classification systems (Nordland et al., 1998).
* No active periodontal diseases and good oral hygiene.
Exclusion Criteria:
* Patients were excluded from the study if they have:
* Spacing or crowding between the teeth to be treated
* Abnormal tooth shape
* Systemic diseases such as diabetes mellitus, hypertension or conditions that alter the outcome of periodontal therapy.
* In addition, patients will be excluded if they are Pregnant and lactating women.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.