Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity (NCT06021262) | Clinical Trial Compass
UnknownNot Applicable
Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity
Egypt90 participantsStarted 2023-08
Plain-language summary
The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are
1. What are the prognostic values of neuroinflammatory markers?
2. What are the genotoxic effects of organophosphates?
3. what are the changes occurring in the levels of traditional oxidative stress and inflammatory markers?
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* For the control group: healthy individuals without previous exposure to organophosphates, with the specified age limits.
* For the acute exposure group: patients with acute exposure to organophosphates, with the specified age limits
* For the chronic exposure group: patients with chronic exposure to organophosphates, with the specified age limits
No restrictions on comorbidities in the three groups except those mentioned under Exclusion Criteria
Exclusion Criteria:
* Pediatric patients.
* Patients with neurological diseases (Parkinsonism, epilepsy, Alzheimer's disease, etc.)
* Patients who does not meet the inclusion criteria.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Identification of neuroinflammatory biomarker
Timeframe: 1.5 years
2
Identification of the mechanism of neuroinflammation