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Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity

Egypt90 participantsStarted 2023-08

Plain-language summary

The aim of this observational study is to answer the following questions in individuals with acute and chronic exposure to organophosphates. The main questions to be addressed are 1. What are the prognostic values of neuroinflammatory markers? 2. What are the genotoxic effects of organophosphates? 3. what are the changes occurring in the levels of traditional oxidative stress and inflammatory markers?

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * For the control group: healthy individuals without previous exposure to organophosphates, with the specified age limits. * For the acute exposure group: patients with acute exposure to organophosphates, with the specified age limits * For the chronic exposure group: patients with chronic exposure to organophosphates, with the specified age limits No restrictions on comorbidities in the three groups except those mentioned under Exclusion Criteria Exclusion Criteria: * Pediatric patients. * Patients with neurological diseases (Parkinsonism, epilepsy, Alzheimer's disease, etc.) * Patients who does not meet the inclusion criteria.

What they're measuring

Identification of neuroinflammatory biomarker

Timeframe: 1.5 years

Identification of the mechanism of neuroinflammation

Timeframe: 1.5 years

Trial details

NCT IDNCT06021262

SponsorAlexandria University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12

Contact for this trial

Ahmed F. El Yazbi, professor

01155881772 Ayazbi@aiu.edu.eg

View on ClinicalTrials.gov More Neuroinflammatory Response trials