An Imaging Study of Polyvascular Disease (NCT06016608) | Clinical Trial Compass
RecruitingNot Applicable
An Imaging Study of Polyvascular Disease
China1,100 participantsStarted 2023-10-18
Plain-language summary
1. Establish a multimodality imaging database for PVD, improve the one-stop screening process for early PVD based on artificial intelligence, build a full-cycle control information platform, and promote the construction and standardization of a multidisciplinary co-morbidity and co-management diagnosis and treatment model.
2. Based on non-invasive, zero-contrast ocular OCTA combined with one-stop CTA imaging of the heart and brain, construct an integrated "eye-heart-brain" early warning model for PVD, and explore a potential non-invasive and convenient early warning system for PVD.
3. Based on the multi-omics, investigate EVs-mediated intercellular communication network, elucidate the roles and regulatory mechanisms of EVs in the development of PVD, search for potential targets for intervention, and construct an artificial intelligence-based "pan-vascular score" risk assessment system based on the combination of multi-modality imaging and multi-omics biomarkers.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patients with coronary artery disease (≥50% stenosis in any coronary artery on coronary angiography)
✓. Age ≥18 years old
✓. Proposed OCT-IVUS integrated imaging system
✓. able to provide written informed consent prior to the start of any procedures related to the study.
✓. patients with coronary artery disease (coronary angiography reveals ≥50% degree of stenosis in any coronary artery) and patients with stroke or TIA (confirmed by a neurologist)
✓. Age ≥ 18 years
✓. able to provide written informed consent prior to the start of any procedures related to the study.
Exclusion criteria
✕. severely tortuous/calcified coronary arteries with anticipated difficulty in completing the OCT-IVUS integrated imaging system
✕. uncontrolled congestive heart failure or acute left heart failure;plan