The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes

Inclusion Criteria: * Middle-aged and older women and men between 40-75 years old * A physician diagnosed type 2 diabetes at least 3 months ago * Treated with an oral hypoglycemic medication * Body mass index \< 40 kg/m2 * Systolic blood pressure \< 160 mmHg * Sedentary (defined as \< 120 min/week of exercise) * Not currently participating in exercise or dietary interventions for at least 2 months prior the present study and willing to abstain from participating in those strategies during the duration of this study. Exclusion Criteria: * \< 40 years of age and \> 65 years of age * Use of medications and/or any supplements that may affect outcome variables (such as arginine- or citrulline-containing supplements, nitrates, and nitroglycerin) * Body mass index ≥ 40 kg/m2 * Systolic blood pressure ≥ 160 mmHg * Recent changes in medications within 3 months * Current smoking any tobacco use * Type 1 diabetes, severe cardiovascular/renal/pulmonary diseases * More than 7 alcoholic drinks/week of consumption * Premenopausal women with an irregular menstrual cycle (oligomenorrhea) or pregnancy