Randomized Controlled Study of Programmed Weaning From NIV for AECOPD (NCT06014034) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Randomized Controlled Study of Programmed Weaning From NIV for AECOPD
China80 participantsStarted 2023-05-12
Plain-language summary
Purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic obstructive pulmonary disease.
Who can participate
Age range
40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* It is defined that in patients with acute exacerbation of chronic obstructive pulmonary disease, the arterial blood gas analysis was decompensation of respiratory acidosis, and the pH value was 7.20-7.35
* Non-invasive mechanical ventilation was performed and it was well tolerated
Exclusion Criteria:
* younger than 40 years old
* pregnancy
* Human immunodeficiency virus (HIV) antibody was positive
* Hemodynamic instability
* Long-term use of home non-invasive ventilators
* Mechanical ventilation for endotracheal intubation and cardiopulmonary resuscitation were disagreed
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is specifically about how to gradually wean patients off non-invasive ventilation (NIV) during a COPD flare-up — is NIV even part of my current treatment plan, and would the weaning approach being studied here be relevant to my situation?
2Since this trial is no longer recruiting new patients, are there similar studies or updated protocols for NIV weaning that my care team is already using or could consider for me?
3The trial is measuring how long it takes to fully come off NIV — what does that mean in practical terms for how many hours a day I'd be on the machine, and how would a structured weaning schedule affect my hospital stay or daily routine?
4Because this is listed as Phase NA, it seems more focused on comparing care strategies than testing a brand-new drug — can you help me understand how the evidence from this kind of study compares to standard NIV weaning practices, and what's currently considered best practice for my stage of COPD?
5Would a programmed weaning approach like the one in this trial be something my care team could still apply to my treatment even though I can't enroll, or is this only available through the trial itself?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Complete evacuation time of non-invasive ventilation
Timeframe: At the end of non-invasive ventilation，through study completion, an average of 11 days