The goal of this clinical trial is to evaluate the short-term clinical outcomes of starting Dapagliflozin on the same day of hospital admission in patients with acute decompensated heart failure (ADHF) with reduced ejection fraction. The main questions it aims to answer are: * Does early initiation of Dapagliflozin improve the length of hospital stay and in-hospital mortality in patients with ADHF? * Does early initiation of Dapagliflozin enhance the diuretic response, weight reduction and pro-BNP reduction in the acute stage of HF? * Does early initiation of Dapagliflozin adversely affect the hemodynamic stability and kidney functions in the acute stage of HF? Participants will be randomized with the ratio of 1:1 within 24 hours of admission to receive Dapagliflozin 10 mg/day versus standard of care. Follow up will continue for 2 months after hospital discharge. Researchers will compare the in-hospital and 60-day clinical outcomes in the Dapagliflozin group versus the standard treatment group.
Age range
18 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
All-cause mortality during hospitalization.
Timeframe: From the date of admission until the date of discharge, average of 7 days
Length of hospital stay
Timeframe: From the date of admission until the date of discharge, average of 7 days
Diuretic response during the hospital phase.
Timeframe: First 4 days of hospital admission
Change in NT-proBNP at day 4 (or at discharge if earlier).
Timeframe: First 4 days of hospital admission