RecruitingNot Applicable

Trendelenburg Position for Acute Anterior Circulation Ischemic Stroke With Large Artery Atherosclerosis Etiology (HOPES 3)

China600 participantsStarted 2024-01-10

Plain-language summary

The effect of head position as a nonpharmacological therapy on acute ischemic stroke (AIS) remains inconclusive. Recent HOPES2 (Head dOwn-Position for acutE moderate ischemic Stroke with large artery atherosclerosis) suggest the safety, feasibility, and potential benefit of the head-down position (HDP) in acute ischemic stroke. The current study aims to investigate the efficacy and safety of HDP in acute moderate ischemic stroke patients with large artery atherosclerosis.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years old * Acute ischemic stroke confirmed by NCCT or MRI; * Moderate neurologic deficit (6≤ NIHSS ≤ 16) within 24 hours of onset, or progressing from mild (NIHSS ≤ 5) to moderate neurologic deficit (6≤ NIHSS ≤ 16) within 24 hours, requiring ≥ 4 point increase in NIHSS score although the onset time is beyond 24 hours; * Probable large artery atherosclerosis etiology based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria (responsible artery stenosis ≥ 50% or occlusion); * Anterior circulation stroke (internal carotid artery, M1 or M2 of middle cerebral artery); * First stroke onset or past stroke without obvious neurological deficit (mRS≤2); * Signed informed consent. Exclusion Criteria: * Pre-stroke disability (mRS≥3); * Patients with disturbance of consciousness; * Patients who plan to undergo or have completed thrombolysis or mechanical thrombectomy; * Hemorrhagic stroke or combined ischemic and hemorrhagic stroke; * Serious comorbidity, such as liver or kidney insufficiency, malignant tumor, etc; * Other stroke etiologies, such as cardiogenic embolism, arteritis, arterial dissection, moyamoya disease, etc; * Previous history of intracerebral hemorrhage within 1 year; * Any contraindication to head-down position (e.g. active vomiting, pneumonia, uncontrolled heart failure); * Planned carotid or intracranial revascularization within 3 months; * Severe uncontrolled hypertension (systolic blood pressure over 180mmHg or dia…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

proportion of favorable functional outcome

Timeframe: 90±7 days

Trial details

NCT IDNCT06010641

SponsorGeneral Hospital of Shenyang Military Region

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-10-30

View on ClinicalTrials.gov More Stroke, Acute Ischemic trials