UnknownNot Applicable

MISOPROSTOL FOR THE TREATMENT OF SUSPECTED POSTPARTUM RETAINED PRODUCTS OF CONCEPTION

Israel150 participantsStarted 2021-02-02

Plain-language summary

The goal of this current study is to evaluate the efficacy of treatment of postpartum patients with suspected retained products of conception (RPOC) with Misoprostol in reducing the frequency of postpartum RPOC compared to a control group of patients that will be managed expectantly, in a prospective randomized trial.

Who can participate

Age range

18 Years – 45 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women between the ages of 18 years - 45 years. * Spontaneous vaginal delivery or vacuum extraction, including VBAC cases * Revision of the uterine cavity or manual lysis of the placenta postpartum * Early postpartum hemorrhage * Cases with a history of treated postpartum residua (by curettage or hysteroscopy) * Placental pathology (succenturiate placenta, bilobed placenta) * Pregnancy that started as a multifetal gestation with only one fetus reached advanced pregnancy * Bumm curettage post-delivery * Patients are able to provide written consent Exclusion Criteria: * Patients with no risk factors of RPOC * Cesarean section on index pregnancy * Cases requiring urgent curettage for late postpartum hemorrhage * Inability to consent due to cognitive or language barrier

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Cases of retained products of conception

Timeframe: 8-16 weeks postpartum

Trial details

NCT IDNCT06009679

SponsorAssuta Ashdod Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-31

Contact for this trial

oshri Barel, MD

+972559382117 oshrib@assuta.co.il

View on ClinicalTrials.gov More Retained Products of Conception trials