CompletedPhase 1

Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers

United States40 participantsStarted 2023-09-28

Plain-language summary

Regional anesthesia decreases postoperative pain scores and opioid consumption, and may prevent chronic pain after surgery in patients undergoing surgery. However, some patients experience an increase of pain into the severe range when the nerve block wears off, also known as rebound pain. The investigators are studying if a nerve block (numbing injection) in the arm causes hyperalgesia (increased pain) when the nerve block is wearing off.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years old, ≤ 65 years old * BMI \>18, \< 35 * Able to speak and understand English * Willingness to undergo psychophysical testing (e.g., QST, pain questionnaires) * Willingness to have nerve block performed Exclusion Criteria: * Ongoing acute or chronic pain in upper extremities * Skin or tissue infection affecting upper extremities * Previous hypersensitivity to mepivacaine or lidocaine * Previous neuropathy (numbness, paresthesia, or motor weakness) in either upper extremity * Loss of any limb * Bleeding issues or bleeding disorder * History of alcohol or drug abuse * Currently pregnant or breastfeeding * History of seizure or epilepsy

What they're measuring

Heat pain detection threshold at time 1 hr

Timeframe: 1 hour after nerve block resolution

Trial details

NCT IDNCT06005480

SponsorBrigham and Women's Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-28

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