CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery. (NCT06005363) | Clinical Trial Compass
UnknownNot Applicable
CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
Taiwan48 participantsStarted 2023-07-01
Plain-language summary
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.
Who can participate
Age range
60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* patients with communicating hydrocephalus for elective VP shunt surgery under general anesthesia
* age\> 60 y/o
* conscious clear
* fluency in Chinese
* anticipated hospital stay ≥ 3 days after surgery
Exclusion Criteria:
* unstable preoperative condition (unstable angina, CHF, asthma attack) within 4 weeks before surgery,
* severe hepatic dysfunction or renal failure
* history of neuropsychological diseases such as schizophrenia, Parkinson's disease, dementia, stroke,
* pre-op cognitive impairment,
* preoperative delirium,
* preoperative depression,
* allergy to contrast medium of MRI.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Postoperative cognitive function
Timeframe: postoperative 2 hours, postoperative day 1, postoperative day 2, postoperative day 3
2
NMR amd LC-MS CSF and plasma metabolomics
Timeframe: preoperative, postoperative 2 hours, postoperative day 1