UnknownNot Applicable

Vaginal Progesterone Improves Clinical Outcomes of RIF Patients

China152 participantsStarted 2023-08-01

Plain-language summary

This study is a single-center, randomized, controlled prospective study. Those patients with repeated implantation failure (RIF) who will recieve frozen thawed embryo transfer (FET) are enrolled in the study. To determine the effect of vaginal progesterone on the clinical pregnancy outcomes of RIF patients.

Who can participate

Age range20 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Aged between 20 and 40 years old;
✓. BMI: 18-28 kg/m2；
✓. Consistent with the diagnosis of repeated implantation failure of unknown reasons, the previous embryo transfer situation meets one of the following:
✓. At least 1 high-quality embryo remained for embryo transfer;
✓. Volunteer to participate in the study and sign the informed consent form.

Exclusion criteria

✕. Patients with recurrent pregnancy loss (≥ 2 biochemical pregnancies or ≥ 2 spontaneous abortions);
✕. Adverse pregnancy history (stillbirth, fetal malformation, etc.);
✕. Severe paternal factors: need for TESA or PESA;
✕. PGT;
✕. Failure of embryo implantation due to any definite reason, including but not limited to: endometrial adhesion (moderate to severe), thin endometrium (\<7 mm before transformation), endometritis, endometriosis (medium or severe), adenomyosis, untreated hydrosalpinx, hysteromyoma (submucosal fibroids, non submucosal fibroids \> 4.0 cm and/or endometrial compression), reproductive malformation, serious immune disease, serious coagulation function abnormality;
✕. Chromosome abnormality of either spouse;
✕. Those with contraindications to pregnancy or assisted reproductive technology.

What they're measuring

Embryo implantation rate

Timeframe: 45 days after embryo transfer

Trial details

NCT IDNCT06005207

SponsorNanjing University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-12-31

Contact for this trial

Chenyang Huang

+862583107188 dianshui19901562@126.com

View on ClinicalTrials.gov More Infertility, Female trials