Not Yet RecruitingNot Applicable

Right Ventricular Dysfunction in Chronic Heart Failure

Italy1,000 participantsStarted 2023-09-01

Plain-language summary

The goal of this multi center observational prospective study is to analyze the concordance between the signs and symptoms of RHF and echocardiographic features of RVD in patient with heart failure. The main questions it aims to answer are: 1. to assess the incidence of RVH and RVD in each HF subtypes. 2. to evaluate prognostic impact ( in terms of cardiovascular mortality and HF hospitalization) of different RVD patterns during a mean followup period of 3 years 3. To investigate the incidence of different RV maladaptation ( isolated RV dilatation, isolated Pulmonary hypertension, combined pattern) in each HF groups and the related outcome. Participants will follow by direct check up visit and/or virtual visits every 6 months for a mean follow-up period of 3 years.

Who can participate

Age range18 Years – 90 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * All patients with a diagnosis of chronic heart failure made according to the recommendations of the ESC guidelines through the simultaneous presence of signs and symptoms of disease associated with BNP and NT proBNP levels \> 100 and 300 pg/ml respectively which are associated with a modest increase PAPS \> 30 mmHg with or without right ventricular dilatation. Exclusion Criteria: * Patients with dyspnea of non-cardiogenic origin, related to systemic respiratory diseases, pulmonary embolism, patients with primary pulmonary hypertension will be excluded. * Patients with heart failure linked to primary valvular pathologies or infiltrative pathologies, secondary and on a genetic basis, patients diagnosed with acute heart failure in non-optimized therapy for at least 3 months will also be excluded. - Patients with systemic inflammatory neoplastic diseases, advanced liver and kidney diseases awaiting transplantation will be excluded.

What they're measuring

Different patterns of RVD in chronic heart failure.

Timeframe: 6 months.

Analyze the incidence and prevalence of RVD and RHF.

Timeframe: 6 months.

Compare the clinical signs of right heart failure with the echocardiographic signs of RVD.

Timeframe: 6 months.

Trial details

NCT IDNCT06002321

SponsorUniversity of Siena

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-03-01

Contact for this trial

Alberto Palazzuoli, MD

+390577585363 palazzuoli2@unisi.it

View on ClinicalTrials.gov More Chronic Heart Failure trials

Plain-language summary

Who can participate

Age range18 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.