Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

Inclusion Criteria: * Heart rate \< 105 beats per minute (BPM)\* * Systolic Blood Pressure \< 160 and \> 90\* * Diastolic Blood Pressure \< 100 and \> 50\* \*Considered out of range if both machine and manual readings are above/below these thresholds. * Body Mass Index (BMI) ≤ 38.0 (at investigator's discretion for higher BMI if no other concurrent health issues) * Current regular user of cannabis who smokes or vapes cannabis or THC extracts at least three days a week for the past 3 months or more * Test positive for D-9-tetrahydrocannabinol (THC) at screening and self-report of cannabis use * Current user of inhaled forms of tobacco/nicotine (cigarette, cigars, e-cigarettes) who use the product daily for the past 3 months or more * Saliva cotinine ≥ 30 ng/mL Exclusion Criteria: * Unstable medical conditions: * Heart disease * Seizures * Cancer * Thyroid disease (okay if controlled with medication) * Diabetes * Hepatitis B or C or Liver disease * Glaucoma * Kidney disease or urinary retention * An ulcer in the past year * Active use of an inhaler for asthma or Chronic Obstructive Pulmonary Disease (COPD) * Hypertension if uncontrolled (meaning participant has a diagnosis, but they are not taking medication/under treatment (e.g., diet or exercise plan) * Drug/Alcohol Dependence * Alcohol or illicit drug dependence within the past 12 months (currently in treatment) with the exception of those who recently completed an alcohol/drug treatment program…