Unraveling the Klinefelter's Disease Physiopathology (NCT05997706) | Clinical Trial Compass
UnknownNot Applicable
Unraveling the Klinefelter's Disease Physiopathology
Belgium20 participantsStarted 2018-06-12
Plain-language summary
Organoid Model to unravel Klinefelter Syndrome infertility
Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men. The investigators will isolate and expand spermatogonial cells from KS patients, then using an organoid model investigators will compare the behavior of these Spermatogonia from KS patients when interacting with four combinations of somatic cell types incorporated in the Extra Cellular Matrix hydrogel.
Who can participate
Age range
5 Years – 50 Years
Sex
MALE
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Klinefelter's infertility physiopathology
Timeframe: Up to 60 days with intermediate time analyses at the 5th and 10 th passage of cultures.
Trial details
NCT IDNCT05997706
SponsorCliniques universitaires Saint-Luc- Université Catholique de Louvain