The goal of this clinical trial is to compare de effect of vitamin K2 in young adults with overweight or obesity. The main questions to answer are: What is the effect of Vitamin K2 supplementation on methylation, serum concentration of ucOC, cOC, Gas6, leptin, inflammatory markers, cardiometabolic risk factors, and cardiovascular risk in overweight or obese young adults? Participants will be assigned to one of two intervention groups where they will consume Vitamin K2 100 µg per day or cornstarch 500 mg per day for 90 days. If there is a comparison group: Investigators will compare the supplementation group (Vitamin K2) with the placebo group (cornstarch) to see if vitamin K2 supplementation modifies methylation, increases serum vitamin K, osteocalcin, growth arrest-specific 6 protein serum concentration, decreases serum leptin concentration, inflammatory markers and reduces cardiometabolic risk factors and cardiovascular risk.
Age range
18 Years – 35 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Osteocalcin serum concentration
Timeframe: Baseline and after 90 days of intervention
Vitamin K serum concentration
Timeframe: Baseline and after 90 days of intervention
Leptin serum concentration
Timeframe: Baseline and after 90 days of intervention
Tumour Necrosis Factor alpha serum concentration
Timeframe: Baseline and after 90 days of intervention
Interleukin-1 Beta serum concentration
Timeframe: Baseline and after 90 days of intervention
Interleukin-6 serum concentration
Timeframe: Baseline and after 90 days of intervention
Interleukin-4 serum concentration
Timeframe: Baseline and after 90 days of intervention
Interleukin-10 serum concentration
Timeframe: Baseline and after 90 days of intervention
Cardiovascular risk
Timeframe: Baseline, after 30, 60 and 90 days of intervention
LEP gene methylation
Timeframe: Baseline and after 90 days of intervention