RecruitingNot Applicable

Changes in Inhibition and Valuation After Eating

United States150 participantsStarted 2023-12-12

Plain-language summary

An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Female * Aged 18 to 45 years * Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2 * Right-handed * English-speaking Additional Inclusion Criteria for Women with Bulimia Nervosa: * Meet DSM-5 criteria for bulimia nervosa Exclusion Criteria: * Medical instability * Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation * Shift work * Pregnancy, planned pregnancy, or lactation during the study period * Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period * Any contraindication for fMRI

What they're measuring

Frontostriatal Activation Associated with Prediction Errors on the Stop Signal Task

Timeframe: 1-2.5 hours after a 16-hour fast (fasted state)

Frontostriatal Activation Associated with Prediction Errors on the Stop Signal Task

Timeframe: 1-2.5 hours after a standardized meal (fed state)

Frontostriatal Activation Encoding the Subjective Value of Cognitive Effort on the Cognitive-Effort Discounting Task

Timeframe: 1-2.5 hours after a 16-hour fast (fasted state)

Frontostriatal Activation Encoding the Subjective Value of Cognitive Effort on the Cognitive-Effort Discounting Task

Timeframe: 1-2.5 hours after a standardized meal (fed state)

Trial details

NCT IDNCT05995496

SponsorIcahn School of Medicine at Mount Sinai

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-12-31

Contact for this trial

Riley Macks, B.A.

(212) 824-9545 riley.macks@mssm.edu

View on ClinicalTrials.gov More Bulimia Nervosa trials

Plain-language summary

Who can participate

Age range18 Years – 45 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Frontostriatal Activation Associated with Prediction Errors on the Stop Signal Task

Timeframe: 1-2.5 hours after a 16-hour fast (fasted state)

Frontostriatal Activation Associated with Prediction Errors on the Stop Signal Task

Timeframe: 1-2.5 hours after a standardized meal (fed state)

Frontostriatal Activation Encoding the Subjective Value of Cognitive Effort on the Cognitive-Effort Discounting Task

Timeframe: 1-2.5 hours after a 16-hour fast (fasted state)

Frontostriatal Activation Encoding the Subjective Value of Cognitive Effort on the Cognitive-Effort Discounting Task

Timeframe: 1-2.5 hours after a standardized meal (fed state)