Active — Not RecruitingNot Applicable

Electroencephalographic Biomarker to Predict Postoperative Delirium

Chile264 participantsStarted 2023-09-01

Plain-language summary

Acute post-operatory cognitive dysfunction states are one of the most important complications in older patients that underwent surgery. Among them postoperative delirium (POD) is the the most studied. Patients who develop delirium have poorer long-term outcomes, such as longer length of hospital stay, institutionalization at discharge, and even higher mortality, and consequently, the human and economic costs significantly increase for the health system. Here the research team will use an observational cohort, investigator blinded in five-center with a primary endpoint to validate intraoperative EEG analysis as a reliable biomarker of postoperative delirium.

Who can participate

Age range60 Years – 100 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 60 years old * Scheduled for high-risk elective surgery * Need for at least 3 days of hospital stay after surgery * Surgery performed under general anesthesia * Written informed consent for participation in the trial Exclusion Criteria: * Patients with preoperative delirium or dementia * Patients using neuroleptics drug during the past 6 months * Patients with a history of encephalopathy, psychosis, stroke or brain trauma with neurologic sequels * The use of ketamine or dexmedetomidine during surgery * Emergency surgery * Mechanical ventilation during the 72 after surgery * Analphabetism * Patients who do not talk Spanish * Patients included in another clinical trial

What they're measuring

Postoperative Delirium

Timeframe: First 3 days after surgery

Trial details

NCT IDNCT05992506

SponsorUniversity of Chile

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-10-31