Background: Human milk oligosaccharides (HMO) and microbiota are both key factors for infants to shape the gut flora and develop the immune system. Breastfed infant is beneficial to prevent the occurrence of infantile colic (IC) and atopic dermatitis (AD), which may through shaping a healthy microbiota. However, the gut microbiota biomarkers representing IC and AD have not yet been discovered. In addition, the effectiveness of supplement of HMO in infant formula reduce the incidence of IC and AD in infants is still debate.
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Incidence of IC and AD will be compared between three groups
Timeframe: The 1 months after birth follow-up
Incidence of IC and AD will be compared between three groups
Timeframe: The 2 months after birth follow-up
Incidence of IC and AD will be compared between three groups
Timeframe: The 4 months after birth follow-up
Incidence of IC and AD will be compared between three groups
Timeframe: The 6 months after birth follow-up
Incidence of IC and AD will be compared between three groups
Timeframe: The 12 months after birth follow-up
Next-generation sequencing analysis-based differences on gut microbiota in infants between three groups
Timeframe: Infant stool samples will be collected at various time points from 0 to 1 year of age.