CompletedNot Applicable

The Effect of Continuous Renal Replacement Therapy on the Efficiency of Extracorporeal CO2 Removal

China10 participantsStarted 2023-04-24

Plain-language summary

In the design of extracorporeal carbon dioxide removal (ECCO2R) combined with continuous renal replacement therapy (CRRT) equipment, in model of continuous veno-venous hemofiltration (CVVH) , the HCO3- concentration in the pre membrane lung blood is diluted by the replacement solution, and a decrease in HCO3- leads to a decrease in PCO2. On the other hand, in continuous veno-venous hemodialysis (CVVHD), HCO3- in post membrane blood will exchange interaction. The exchange results of HCO3- determine the impact of CVVHD on the CO2 removal efficiency of the ECCO2R combined CRRT system. This study aims to investigate the effects of CVVH and CVVHD on in vitro CO2 clearance efficiency.

Who can participate

Age range18 Years – 85 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Using Extracorporeal carbon dioxide removal combined with continuous renal replacement therapy * 18 years ≤ age ≤ 85 years; Exclusion Criteria: * Severe hemodynamic instability (increased dosage of vasoactive drugs or MAP ≤ 65mmHg within two hours); * Severe electrolyte deficiency (including severe hyponatremia (blood sodium\<130mmol/L) and hypokalemia (blood potassium\<3.0mmol/L)); * Participate in other intervention studies within 30 days; * Do not consent this research

What they're measuring

extracorporeal CO2 removal rate

Timeframe: after 30min of continuous renal replacement therapy

Trial details

NCT IDNCT05989971

SponsorSoutheast University, China

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-12-31

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