Major Depressive Disorder (MDD) is a common mental health diagnosis. While there are many approaches to the treatment of MDD, current treatments of MDD often do not substantially reduce depressive symptoms among those in need of care. Prior research suggests that combining cognitive-behavioral therapy (CBT) and psychopharmacology can produce optimal treatment outcomes compared to the use of either treatment individually. Transcranial Magnetic Stimulation (TMS) is one promising brain stimulation approach used to treat MDD, especially among patients with treatment-resistant symptoms. Like psychopharmacological interventions, TMS may produce optimal treatment outcomes when paired with CBT. However, standard TMS protocols are time-intensive, typically requiring daily doctor visits for one hour of six to eight weeks. Therefore, an internet-delivered CBT protocol may augment the effects of TMS without substantially increasing patient burden. To that end, the present study assesses if a combined TMS and internet-delivered CBT protocol may produce superior treatment outcomes compared with TMS alone.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Hamilton Depression Rating Scale (HAM-D)
Timeframe: Baseline to Post-Treatment (6 weeks)
Temporal Experience of Pleasure Scale (TEPS)
Timeframe: Baseline to Post-Treatment (6 weeks), as well as 6-month and 9-month follow-up
Inventory of Depressive Symptomatology (IDS)
Timeframe: Baseline to Post-Treatment (6 weeks)
Dimensional Anhedonia Rating Scale (DARS)
Timeframe: Baseline to Post-Treatment (6 weeks), as well as 6-month and 9-month follow-up