Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1… (NCT05985135) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus
United States70 participantsStarted 2026-06-01
Plain-language summary
This research is being done to better understand how insulin effects muscle, blood, and the body in people with Type 1 Diabetes.
Who can participate
Age range18 Years – 70 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria - Type 1 Diabetes Group:
\- Able to provide written consent.
Exclusion Criteria - Type 1 Diabetes Group::
* BMI \< 20 or \> 32 kg/m\^2.
* Celiac disease.
* Pregnancy.
* Smoking.
* Reported history of illicit substance use.
* History of active cardiovascular, cerebrovascular, or peripheral vascular disease.
* Active renal disease evidenced by estimated glomerular filtration rate (GFR) \< 50 mL/min/1.73 m\^2.
* Severe peripheral or autonomic neuropathy.
* Dementia or any other neurologic disease.
* Uncontrolled psychiatric disease.
* Any learning disability.
* Anemia.
* Thyroid-stimulating hormone (TSH) ≥ 7 or TSH ≤ 7 and free T4 ≤ 0.9.
* Hemoglobin A1c \> 9.0%.
* Type 2 Diabetes Mellitus (T2DM), or impaired fasting glucose.
* Detectable C peptide.
Inclusion Criteria - Control Group:
* Able to provide written consent.
* T1DM treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI) (not Degludec).
Exclusion Criteria - Control Group:
* BMI \< 20 or \> 32 kg/m\^2.
* Celiac disease.
* Pregnancy.
* Smoking.
* Reported history of illicit substance use.
* History of active cardiovascular, cerebrovascular, or peripheral vascular disease.
* Active renal disease evidenced by estimated GFR \< 50 mL/min/1.73 m\^2.
* Severe peripheral or autonomic neuropathy.
* Dementia or any other neurologic disease.
* Uncontrolled psychiatric disease.
* Any learning disability.
* Anemia.
* TSH ≥ 7 or TSH ≤ 7 and free T4 ≤ 0.9.
* T2DM, or im…