Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1… (NCT05985135) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus
United States70 participantsStarted 2026-06-01
Plain-language summary
This research is being done to better understand how insulin effects muscle, blood, and the body in people with Type 1 Diabetes.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria - Type 1 Diabetes Group:
\- Able to provide written consent.
Exclusion Criteria - Type 1 Diabetes Group::
* BMI \< 20 or \> 32 kg/m\^2.
* Celiac disease.
* Pregnancy.
* Smoking.
* Reported history of illicit substance use.
* History of active cardiovascular, cerebrovascular, or peripheral vascular disease.
* Active renal disease evidenced by estimated glomerular filtration rate (GFR) \< 50 mL/min/1.73 m\^2.
* Severe peripheral or autonomic neuropathy.
* Dementia or any other neurologic disease.
* Uncontrolled psychiatric disease.
* Any learning disability.
* Anemia.
* Thyroid-stimulating hormone (TSH) ≥ 7 or TSH ≤ 7 and free T4 ≤ 0.9.
* Hemoglobin A1c \> 9.0%.
* Type 2 Diabetes Mellitus (T2DM), or impaired fasting glucose.
* Detectable C peptide.
Inclusion Criteria - Control Group:
* Able to provide written consent.
* T1DM treated with continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI) (not Degludec).
Exclusion Criteria - Control Group:
* BMI \< 20 or \> 32 kg/m\^2.
* Celiac disease.
* Pregnancy.
* Smoking.
* Reported history of illicit substance use.
* History of active cardiovascular, cerebrovascular, or peripheral vascular disease.
* Active renal disease evidenced by estimated GFR \< 50 mL/min/1.73 m\^2.
* Severe peripheral or autonomic neuropathy.
* Dementia or any other neurologic disease.
* Uncontrolled psychiatric disease.
* Any learning disability.
* Anemia.
* TSH ≥ 7 or TSH ≤ 7 and free T4 ≤ 0.9.
* T2DM, or im…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.