Primary melanocytic tumors of the central nervous system are rare lesions and occur develop from leptomeningeal melanocytes. The WHO classification of tumors of the central nervous system in its most recent version (2021) distinguishes on the one hand the circumscribed melanocytic tumors including melanocytoma, benign, and its slope malignant, meningeal melanoma, with an intermediate grade lesion in between, called intermediate grade melanocytoma. They are to be distinguished from diffuse tumors or multifocal diseases such as melanocytosis and its malignant corollary, melanomatosis. The main current challenge is to distinguish them from their differential diagnoses, namely metastasis of a cutaneous or extrac-cutaneous melanoma mainly and on the other hand other pigmented entities occuring in the CNS such as malignant melanic tumor of the peripheral nerve sheath (MMNST, formerly "melanotic schwannoma").
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Diagnosis according to WHO classification of CNS tumors (5th edition)
Timeframe: at baseline (initial report)
Mitotic index
Timeframe: at baseline (initial report)
Age
Timeframe: At baseline
Sex
Timeframe: At baseline
Ki-67
Timeframe: At time of initial diagnosis
T1-weighted sequence signal
Timeframe: At time of initial diagnosis
Enhancement after gadolinium injection
Timeframe: At time of initial diagnosis