Chronic constipation is a heterogeneous disease with multiple symptoms, and its incidence is on the rise in many countries. It has become a common disease affecting the quality of life. When these patients fail to respond to standardized and systematic non-surgical treatment, and the relevant examination suggests that there are surgical indications, surgical treatment should be considered. TThe objective of this study was to explore the efficacy and safety of surgical treatment for constipation, as well as the changes in postoperative nutrition, intestinal motility, intestinal flora and quality of life.
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The nutritional status of the patients was assessed according to the scores of nutritional risk screening and assessment tool Nutritional Risk Screening2022（NRS2002)
Timeframe: Baseline and 1、6、12 and 24 months after surgery
The nutritional status of the patients was assessed according to the scores of nutritional risk screening and assessment tool Malnutrition Universal Screening Tool （MUST).
Timeframe: Baseline and 1、6、12 and 24 months after surgery
The nutritional status of the patients was assessed according to the scores of nutritional risk screening and assessment tool Mini Nutritional Assessment （MNA).
Timeframe: Baseline and 1、6、12 and 24 months after surgery
The peristalsis status of patients was evaluated according to the frequency of defecation and the character of feces.
Timeframe: Baseline and 1、6、12 and 24 months after surgery
The changes of fecal microbiota were detected by 16SDNA sequencing.
Timeframe: Baseline and 1、6、12 and 24 months after surgery
Quantitative changes in immune cells were determined by flow cytometry of blood samples.
Timeframe: Baseline and 1、6、12 and 24 months after surgery
Changes of intestinal motility after surgical treatment for constipation.
Timeframe: Baseline and 1、6、12 and 24 months after surgery
Changes of defecation after surgical treatment for constipation.
Timeframe: Baseline and 1、6、12 and 24 months after surgery
Changes of quality of life after surgical treatment for constipation.
Timeframe: Baseline and 1、6、12 and 24 months after surgery