Endogenous Lithium Clearance in Acute Kidney Injury
Norway20 participantsStarted 2023-08-01
Plain-language summary
Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness.
Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ICU patients diagnosed with AKI, without AKI and healthy controls
Exclusion Criteria:
\-
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial has already been completed, would it be possible to look at any published results showing whether lithium clearance measurements were actually useful for detecting how well the proximal tubule is working during sepsis-related kidney injury?
2This study used lithium clearance as a way to measure kidney tubule function — is that something my care team already tracks, or is it a technique that's not yet standard in routine care for acute kidney injury?
3Because this was a non-interventional, measurement-focused study rather than a treatment trial, does it have any direct implications for changing how my kidney function would be monitored if I develop acute kidney injury from sepsis?
4Given that sepsis-related acute kidney injury can progress quickly, how would a better understanding of proximal tubule function — like what this trial was studying — potentially change the timing or type of treatment decisions my doctors might make?
5Are there any follow-up studies or treatment trials stemming from this research that might be relevant to discuss as options if I'm at risk for sepsis-related kidney injury?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.