Experimental Pain in Parkinsons (NCT05981261) | Clinical Trial Compass
RecruitingNot Applicable
Experimental Pain in Parkinsons
Denmark63 participantsStarted 2023-06-07
Plain-language summary
Study comparing pain intensity and discomfort in patients with Parkinson´s disease and healthy controls during inducement of mechanical, thermal, and chemical experimental pain
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
* Group healthy volunteers: healthy subjects with no PD diagnosis
* Group PD patients levodopa: Include PD patients treated with levodopa
* Group PD patients DBS: Include PD patients with DBS Exclusion criteria
* Known other neurological or medical disorders (e.g., stroke, neuropathy, diabetes) or other disorders with expected influence on experimental pain
* Known dementia (a score \<24 on the MoCA)
* Known untreated depression (a score ≥15 on the Beck Depression Inventory)
* Unable to cooperate
* Treated with painkillers except paracetamol and NSAID (except if pain and treatment is ad-equately stable as evaluated by a doctor)
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Thermal induced heat pain
Timeframe: Immediately after assessment of ongoing pain (15 minutes)
2
Mechanical induced pain
Timeframe: Immediately after assessment of thermal induced heat pain (15 minutes)
3
Chemical induced pain
Timeframe: Immediately after assessment of mechanical pain (15 minutes)
4
Ongoing pain (Clinical pain in daily life)
Timeframe: After assessment of motor response latencies measure (15 minutes)
5
Ongoing pain (Sensory and affective verbal descriptions of pain and patient drawings)
Timeframe: After assessment of motor response latencies measures (15 minutes)
6
Ongoing pain (Pain in PD)
Timeframe: After assessment of motor response latencies measures (15 minutes)