Comparing Chemoprevention Drugs for School-based Malaria Control

Inclusion Criteria: Students (enrolled in the primary intervention) * Previously enrolled in NCT05244954 * Currently enrolled in the study school * Plan to attend the study school for the remainder of the school year * Parent/guardian available to provide written informed consent Younger children in participant households (enrolled in the Household Prevalence survey) * Slept in the household for most nights in the last month * Age 6-59 months * Parent/guardian available to provide written informed consent Exclusion Criteria: Students (enrolled in the primary intervention) * Current evidence of severe malaria or danger signs * Known adverse reaction to the study drugs * History of cardiac problems or fainting * Taking medications known to prolong QT * Family history of prolonged QT * Taking trimethoprim-sulfamethoxazole aka Bactrim or Cotrimoxazole * Epilepsy * Psoriasis Household members (enrolled in the Household Prevalence survey) * Household with more than one school-age child enrolled in the study * Current evidence of severe malaria or danger signs