Active — Not RecruitingNot Applicable

Metagenomic NGS for Diagnosis of Pneumonia

Taiwan114 participantsStarted 2023-08-07

Plain-language summary

In this randomized controlled trial, we aim to evaluate the efficacy of incorporating mNGS in the management of pneumonia on efficiency and accuracy of causative pathogen identification, proportion of participants with effective antimicrobial therapy, length of hospitalization, and mortality.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Presenting to the ICU with a diagnosis of pneumonia (fulfilled with both radiographic and clinical criteria)
✓. Adults aged ≥18 years
✓. Orotracheally intubated
✓. ICU admission for \<24 hours
✓. APACHE II score \<35 on ICU admission

Exclusion criteria

✕. Life expectancy below 4 weeks
✕. With an existing directive to withhold life-sustaining treatment
✕. Patients not willing or able to provide a lower respiratory tract sample at ICU admission
✕. Previous work-up has identified specific pathogens which can account for the index event of pneumonia
✕. Multiplex PCR or NGS testing has been done for pathogen detection before screening

What they're measuring

Time to achieving definite diagnosis in modified intention-to-treat (mITT) analysis.

Timeframe: 7 days

Trial details

NCT IDNCT05979350

SponsorNational Taiwan University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-20

View on ClinicalTrials.gov More Pneumonia trials