Physiological and Sensory Responses to Prolonged Fasting in Humans (NCT05977569) | Clinical Trial Compass
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Physiological and Sensory Responses to Prolonged Fasting in Humans
United Kingdom7 participantsStarted 2021-06-28
Plain-language summary
This study aims to establish the metabolic/molecular response in both adipose tissue and skeletal muscle as well as sensory experiences (pain, fatigue, drive) to prolonged fasting of 3 days duration. Participants will undergo sequential meal assessment before and after a 3 day fast with measures taken throughout each fasting day.
Who can participate
Age range
18 Years – 45 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* • Body mass index 20.0-29.9 kg∙m-2
* Age 18-45 years
* Willing to abstain from food intake for just over 3 days (\~82 hours)
* Able and willing to provide informed consent and safely comply with study procedures
* Females to maintain record of regular menstrual cycle phase or contraceptive use
* No anticipated changes in lifestyle during the study (e.g. holidays or exercise programmes)
Exclusion Criteria:
* • Any reported condition or behaviour deemed either to pose undue personal risk to the participant or introduce bias
* Any diagnosed metabolic disease (e.g. type 1 or type 2 diabetes)
* Any reported use of substances which may pose undue personal risk to the participants or introduce bias into the experiment
* Pregnancy
* Breastfeeding
* Lifestyle not conforming to standard sleep-wake cycle (e.g. shift worker)
* History of eating disorders (e.g. anorexia)
* Any reported recent (\<6 months) change in body mass (± 3%)
* Uncontrolled hyperthyroidism
* Advanced cerebrovascular insufficiency or dementia
* Advanced liver or kidney insufficiency
* History of migraine and or headache
* Psychotic disorders
* Unstable or severe coronary artery disease
* Retinal detachment
* Duodenal or stomach ulcer
* Cancer and malignant disease
* Regular use of Non-steroidal anti-inflammatory drugs (NSAIDs)
* Use of Systemic corticoids
* Use of Antihypertensives (especially beta-blockers and diuretics)
* Use of Antidiabet…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.