UnknownNot Applicable

Characterization of Tissue Biochemical Composition in Gastric Precancerous/Cancerous Lesions

Singapore25 participantsStarted 2022-10-27

Plain-language summary

This is a study intended to utilize endoscopic biopsies from gastric precancerous/ cancerous lesions and adjacent normal mucosa to characterize tissue biochemical composition changes as determined by mass spectrometry lipidomic/ proteomic profiling, and correlate these changes with histopathologic results, and Raman spectra as determined by SPECTRA IMDx™. The study site will be National University Hospital.

Who can participate

Age range21 Years

SexALL

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Inclusion criteria

✓. They are aged 21 years and above
✓. They will be undergoing upper gastrointestinal endoscopy for any of the following:
✓. Current or known history of gastric dysplasia and gastric cancer, or
✓. Endoscopic surveillance after previous endoscopic or surgical resection for gastric dysplasia or gastric cancer.
✓. They must be mentally competent.
✓. They must be willing and able to comply with all study procedures.

Exclusion criteria

✕. Subjects with bleeding disorders, such as haemophilia, in whom biopsies are contraindicated.
✕. Subjects with active bleeding or coagulopathy precluding biopsies.
✕. Pregnant subjects.
✕. The subject with severe co-morbid illness, such as end-stage renal failure (ESRF), congestive cardiac failure (CCF) and advanced liver cirrhosis.
✕. Subjects with other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may interfere with the interpretation of study results or would make the subject unsuitable for entry into the study

What they're measuring

Correlating tissue biochemical composition with the Raman spectra and histopathologic results to differentiate between the gastric disease states based on distinct features in the biochemical composition of pre-cancerous / cancerous lesions.

Timeframe: 18 moths

Trial details

NCT IDNCT05977478

SponsorNational University Hospital, Singapore

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

Contact for this trial

Guowei Kim, MBBS

+65-67725555 guo_wei_kim@nuhs.edu.sg

View on ClinicalTrials.gov More Gastric Cancer trials