CompletedNot Applicable

Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients

United States107 participantsStarted 2023-11-01

Plain-language summary

The goal of this prospective randomized study is to improve antibiotic use among hospitalized patients with suspected pneumonia. An alert was built into the electronic health record to guide use of diagnostic testing based on probability of bacterial pneumonia. Patients with test results suggesting viral infection will be randomized to either: (1) receive a structured communication from the antimicrobial stewardship team to de-escalate antibiotics or (2) usual care.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Adult patients admitted to the University of Maryland Medical Center or University of Maryland Medical Center-Midtown Campus who are prescribed antibiotics for suspected community-acquired respiratory infection. * Protocol-based diagnostic testing supports possible viral infection, either by positive molecular test or low procalcitonin value. Exclusion Criteria: * Hospitalization for \>72 hours prior to protocol-based diagnostic testing. * Previous molecular testing for viral infection during the same hospital encounter. * Severely immunosuppressed, defined as having hematologic malignancy, solid organ tumor on chemotherapy, or solid organ transplant on immunosuppression

What they're measuring

Hospital antibiotic days of therapy

Timeframe: Up to 90 days after randomization

Trial details

NCT IDNCT05976581

SponsorJonathan Baghdadi

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-01-10

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